翻訳と辞書 Words near each other ・ Interleukin 36 receptor antagonist ・ Interleukin 37 ・ Interleukin 4 ・ Interleukin 5 ・ Interleukin 5 receptor alpha subunit ・ Interleukin 6 ・ Interleukin 7 ・ Interleukin 8 ・ Interleukin 8 receptor, alpha ・ Interleukin 8 receptor, beta ・ Interleukin 9 ・ Interleukin receptor ・ Interleukin-1 receptor ・ Interleukin-1 receptor family ・ Interleukin-1 receptor-associated kinase ・ Interleukin-1 receptor–associated kinase 4 deficiency ・ Interleukin-10 receptor ・ Interleukin-11 receptor ・ Interleukin-12 receptor ・ Interleukin-13 receptor ・ Interleukin-15 receptor ・ Interleukin-17 receptor ・ Interleukin-18 receptor ・ Interleukin-20 receptor ・ Interleukin-21 receptor ・ Interleukin-22 receptor ・ Interleukin-23 receptor ・ Interleukin-27 receptor ・ Interleukin-28 receptor ・ Interleukin-3 receptor Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Interleukin-1 receptor–associated kinase 4 deficiency ： ウィキペディア英語版 Interleukin-1 receptor–associated kinase 4 deficiency Members of interleukin-1 receptor (Il-1R) and the Toll-like receptor superfamily share an intracytoplasmic Toll-IL-1 receptor (TLR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. Three unrelated, otherwise healthy children with recurrent pyogenic infections due to pneumococci and staphylococci had normal immunocompetence by standard immune studies. They had normal titers of antipneumococcal antibodies. However, their blood and fibroblast cells did not activate nuclear factor κB and mitogen-activated protein kinase and failed to induce downstream cytokines in response to any of the known ligands of TIR-bearing receptors. Each was found to have an inherited deficiency of IRAK-4. Thus, the TIR-IRAK signaling pathway appears to be crucial for protective immunity against specific bacteria but is redundant against most other microorganisms.〔 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Interleukin-1 receptor–associated kinase 4 deficiency」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.